Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer.
AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) focused on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at Stemcentrx, AbbVie's South San Francisco, CA location.
Associate Scientist II– Vector & Cell Engineering – Antibody Discovery
As part of a talented and multi-disciplinary team advancing exciting new approaches to drug discovery and development, AbbVie Stemcentrx is looking for a highly motivated associate scientist with experience in the engineering and characterization of over-expressing or knock down mammalian cell lines in support of the identification and validation of novel targets. This role is based at Stemcentrx and will contribute to a world-class team in identifying novel cancer stem cell targets and developing targeted antibody drug conjugate (ADC) therapies in oncology. The successful candidate will participate in all activities related to constructing new lentiviral vectors: vector construction, transfection, viral titration, and analysis of transduced cells; and assist in the development and optimization of novel approaches for characterizing target biology.
* Engineer overexpression or knock down stable cell lines using lentiviral based gene delivery system
* Clone expression vector and produce lentivirus
* Characterize protein expression using flow cytometric methods, immunoblotting, or ELISA
* Develop new technologies to manipulate cell line modification methods
* Participate in the development and conduct of laboratory meetings, updating group members on background and status of projects by giving oral updates or internal presentations
* Work closely with multiple research teams in a fast-paced discovery-oriented environment
* BS or equivalent education with 3 years of experience, MS or equivalent education with 1 year of experience
* Proficient in mammalian cell culture and DNA cloning strategies
* Hands on experience with lentivirus production
* Experience in flow cytometric methods, immunoblotting and qRT-PCR
* CRISPR-Cas9 experience highly preferred
* Highly motivated, organized, and disciplined record keeping
* Able to work independently or under minimal supervision to design and conduct experiments, as well as interpret, document and communicate results
Equal Opportunity Employer Minorities/Women/Veterans/Disabled
Location/Region: South San Francisco